Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions

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the three-component reaction of 2-(2-oxopropyl)isoindoline-1,3-dione with alkyl isocyanides and aromatic carboxylic acids under catalyst-free conditions in water

a green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. the methods used to follow the reactions are tlc and nmr, which indicated that there...

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ژورنال

عنوان ژورنال: ACS Omega

سال: 2019

ISSN: 2470-1343,2470-1343

DOI: 10.1021/acsomega.9b00406